Multiple calcifying epithelial odontogenic tumor: case report and review of the literature

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm, and few cases of multiple lesions have been published. This article reports the case of a 26-year-old male patient with bilateral gingival lesions near the maxillary canines and a hard tumor on the left side of the mandible. All lesions presented mixed radiographic appearance (radiolucent and radiopaque). Incisional biopsies revealed typical histopathologic findings of CEOT. The gingival lesions were removed by curettage, and the mandibular tumor was surgically resected. No recurrence was detected after 6 years of treatment. Five well-documented cases of multiple CEOT were retrieved from the PubMed database. These patients were slightly older than those with solitary tumors, and none of them presented syndromic features. Three cases had only multiple central tumors, and the other 2 had multiple peripheral lesions, so the present patient is the first to manifest with both central and peripheral tumors.