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Enlarged basal ganglia perivascular spaces and sleep parameters. A population-based study
Oscar H Del Brutto1, Robertino M Mera2, Victor J Del Brutto3
1School of Medicine, Universidad Espíritu Santo - Ecuador, Guayaquil, Ecuador.
Clinical Neurology and Neurosurgery
|May 13, 2019
Summary
Poor sleep efficiency in older adults is linked to enlarged perivascular spaces (PVS) in the basal ganglia. This suggests sleep quality may impact brain waste clearance pathways.
Area of Science:
- Neuroscience
- Sleep Medicine
- Radiology
Background:
- Perivascular spaces (PVS) are crucial for brain fluid and waste clearance, primarily during sleep.
- Sleep disorders may contribute to PVS dilatation, but associations with basal ganglia (BG) PVS are not well understood.
Purpose of the Study:
- To investigate the relationship between sleep parameters and enlarged basal ganglia PVS in older adults.
- To determine if sleep quality, efficiency, or apnea-hypopnea index (AHI) correlate with enlarged BG-PVS.
Main Methods:
- Cross-sectional study of 338 older adults (≥60 years) using Pittsburgh Sleep Quality Index and MRI.
- A subset of 97 participants underwent polysomnography (PSG).
- Logistic regression adjusted for demographics, cardiovascular risk factors, and cerebral small vessel disease.
Main Results:
- Sleep quality showed a univariate association with enlarged BG-PVS, which was not significant after adjusting for confounders.
- Poor sleep efficiency was significantly associated with enlarged BG-PVS (p=0.045).
- No significant association was found between the apnea-hypopnea index (AHI) and enlarged BG-PVS.
Conclusions:
- Poor sleep efficiency is an independent predictor of enlarged basal ganglia PVS in older adults.
- Findings suggest sleep quality influences structural changes in brain perivascular spaces.
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