Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

639
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
639
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

973
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
973
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

424
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
424
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

312
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
312
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

857
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
857
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

286
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
286

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determinants of Major Adverse Kidney Events in Extracorporeal Membrane Oxygenation Survivors.

Critical care explorations·2022
Same author

Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury.

Congenital heart disease·2019
Same author

Acute kidney injury.

Lancet (London, England)·2019
Same author

Bacteriophage-mediated identification of bacteria using photoacoustic flow cytometry.

Journal of biomedical optics·2019
Same author

The Role of Biomarkers in Acute Kidney Injury.

Critical care clinics·2019
Same author

The Janus faces of bicarbonate therapy in the ICU: con.

Intensive care medicine·2019

Related Experiment Video

Updated: Jan 25, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.9K

Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients.

Marco Fiorentino1,2, Fadi A Tohme1, Raghavan Murugan1,3

  • 1The Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Blood Purification
|May 13, 2019
PubMed
Summary

Plasma neutrophil gelatinase-associated lipocalin (pNGAL) and B-type natriuretic peptide (pBNP) can enhance predictions of acute kidney injury (AKI) recovery when combined with clinical factors. These biomarkers show promise in improving patient outcome assessments post-AKI.

Keywords:
Acute kidney injuryBiomarkersNeutrophil gelatinase-associated lipocalinRenal recoveryRenal replacement therapy

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.9K
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

40.8K

Related Experiment Videos

Last Updated: Jan 25, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.9K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.9K
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

40.8K

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Clinical Prediction Models

Background:

  • Acute kidney injury (AKI) biomarkers are explored for predicting renal recovery.
  • Definitions of recovery and patient inclusion criteria can impact study outcomes.

Purpose of the Study:

  • To validate plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a biomarker for AKI recovery prediction.
  • To assess if pNGAL and plasma B-type natriuretic peptide (pBNP) improve existing clinical prediction models for AKI recovery.

Main Methods:

  • Analysis of 69 patients from the Acute Renal Failure Trial Network study.
  • Measurement of pNGAL and pBNP on days 2, 7, and 14 post-AKI.
  • Evaluation of predictive ability for recovery defined as alive and dialysis-independent at 60 days.

Main Results:

  • Neither pNGAL nor pBNP alone accurately predicted renal recovery.
  • The best clinical model (AUC 0.69) outperformed individual biomarkers.
  • Adding pNGAL and pBNP to the clinical model significantly improved recovery prediction (p=0.008).

Conclusions:

  • Plasma neutrophil gelatinase-associated lipocalin (pNGAL) and plasma B-type natriuretic peptide (pBNP) can enhance the accuracy of clinical parameters for predicting AKI recovery.
  • A comprehensive model incorporating biomarkers and age demonstrates adequate discrimination for AKI recovery.