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Association between fragmented QRS and left ventricular dysfunction in acromegaly patients
Seçkin Dereli1, Hatice Özer2, Nurtaç Özer1
1Deparment of Cardiology, Ordu State Hospital, Ordu, Turkey.
Acta Cardiologica
|May 14, 2019
Summary
Fragmented QRS (fQRS) is common in acromegaly patients and predicts myocardial performance index (MPI) and left ventricular (LV) dysfunction. The presence of fQRS may indicate acromegalic cardiomyopathy development.
Area of Science:
- Cardiology
- Endocrinology
- Medical Imaging
Background:
- Acromegaly can lead to heart failure independent of traditional risk factors, suggesting a specific acromegalic cardiomyopathy.
- Fragmented QRS (fQRS) is a potential indicator of cardiac abnormalities.
Purpose of the Study:
- To evaluate the frequency of fQRS in acromegaly patients.
- To assess left ventricular (LV) functions in acromegaly patients with fQRS.
Main Methods:
- Sixty acromegaly patients were included in the study.
- Conventional echocardiography and tissue Doppler imaging were performed.
- Patients were categorized into groups with and without fQRS.
Main Results:
- Significant differences in disease duration, LV end-diastolic volume, E velocity, E/A ratio, E' velocity, E/E' ratio, isovolumic relaxation time (IVRT), and MPI were observed between groups.
- Disease duration, E', and fQRS were independent predictors of MPI.
- Disease duration, E/E', IVRT, and MPI were independent predictors of fQRS.
Conclusions:
- fQRS is frequent in acromegaly patients and independently predicts MPI, which is associated with LV dysfunction.
- fQRS may serve as an indicator for the development of acromegalic cardiomyopathy.
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