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Updated: Jan 25, 2026
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Does BCR-ABL transcript type influence the prognosis of patients in chronic myelogenous leukemia chronic phase?
T P de Almeida Filho1, P A Maia Filho1, Maritza Cavalcante Barbosa1
1Departament of Hematology, Walter Cantidio University Hospital, Fortaleza, Ceara Brazil.
Insights
This study found that BCR-ABL transcript type does not impact hematological, clinical parameters, or event-free survival in chronic myeloid leukemia patients. These findings suggest transcript type is not a significant prognostic factor in this disease.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
- The BCR-ABL fusion gene is a hallmark of CML.
- Different BCR-ABL transcript types exist, but their clinical significance is debated.
Purpose of the Study:
- To investigate the influence of BCR-ABL transcript type on clinical and hematological parameters.
- To assess the impact of transcript type on event-free survival in CML patients.
Main Methods:
- Retrospective review of medical records from 55 CML patients.
- Analysis of baseline hematological and clinical data.
- Data collection on BCR-ABL transcript types (b2a2, b3a2, b2a2/b3a2).
Main Results:
- No significant differences were observed in platelet counts, other hematological parameters, or spleen/liver size based on transcript type.
- No statistical significance was found between risk scores and transcript type.
- Event-free survival probabilities at 21 months varied across transcript types but did not reach statistical significance.
Conclusions:
- BCR-ABL transcript type does not appear to influence hematological, clinical parameters, or event-free survival in chronic phase CML.
- Transcript type may not be a reliable prognostic indicator for CML patients.
Introduction And Objective:
In this study, we evaluated the influence of the transcript type on hematological and clinical parameters, as well as the event-free survival of 50 patients in the Chronic myeloid leukemia chronic phase.
Methods:
We reviewed the medical records of 55 patients with Chronic myeloid leukemia. The eligibility criteria were based on the availability of hematological and clinical baseline data in the medical records. Data on BCR-ABL transcripts were obtained from medical records.
Results:
Eighteen patients (36%) had the b2a2 transcript, 24 (48%) had b3a2 and 8 (16%) had b2a2/b3a2. The median platelet count for transcripts b2a2, b3a2 and b2a2/b3a2 was 320.65×103/L, 396×103/L, and 327.05×103/L, respectively (p=0.896). We could not find any differences in relation to the other hematological parameters, when compared to the transcript type. Comparison between spleen and liver size and type of transcript did not differ inside the groups (p=0.395 and p=0.647, respectively) and the association between risk scores and transcript type did not show statistical significance (p>0.05). The 21-month probability for event-free survival was 21%, 48% and 66% for the transcripts b2a2, b3a2 and b2a2/b3a2 respectively (p=0.226) CONCLUSION: We conclude that the expression BCR-ABL transcripts have no influence on hematological, clinical and event-free survival parameters of patients in the Chronic myeloid leukemia chronic phase.
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