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Hormonal Replacement Therapy in Heart Failure: Focus on Growth Hormone and Testosterone

Andrea Salzano1, Roberta D'Assante2, Mark Lander3

  • 1Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK; Department of Translational Medical Sciences, Federico II University, Via Pansini 5, Naples 80138, Italy.

Heart Failure Clinics
|May 14, 2019
PubMed

Insights

Heart failure (HF) may stem from multiple hormone deficiencies, particularly growth hormone and testosterone. Hormone replacement therapy offers a promising, innovative treatment approach for improving cardiovascular outcomes in HF patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Heart failure (HF) is increasingly viewed as a syndrome involving multiple hormone deficiencies.
  • Anabolic hormone deficiencies are common in HF and linked to poor cardiovascular performance and outcomes.
  • Growth hormone and testosterone deficiencies are particularly significant in HF pathophysiology.

Purpose of the Study:

  • To review the current evidence on growth hormone and testosterone deficiencies in heart failure.
  • To explore the role of these deficiencies in cardiovascular performance and patient outcomes.
  • To discuss novel findings regarding hormone replacement therapy as a treatment for HF.

Main Methods:

  • Systematic review of existing literature on hormone deficiencies in HF.
  • Analysis of studies investigating the impact of hormone deficiencies on cardiovascular outcomes.
  • Evaluation of evidence for hormone replacement therapies in HF patients.

Main Results:

  • Deficiencies in anabolic hormone axes are prevalent in HF patients.
  • These deficiencies correlate strongly with diminished cardiovascular function and adverse outcomes.
  • Hormone replacement therapy shows potential as an innovative treatment strategy.

Conclusions:

  • Heart failure can be conceptualized as a multiple hormone deficiency syndrome.
  • Addressing growth hormone and testosterone deficiencies is crucial for managing HF.
  • Hormone replacement therapy warrants consideration as a novel therapeutic option in HF.

Keywords:
Cardiovascular diseaseGrowth hormoneHeart failureHormonesPrognosis outcomeTestosteroneTherapy

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