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Naturally Occurring Shear Waves in Healthy Volunteers and Hypertrophic Cardiomyopathy Patients

Mihai Strachinaru1, Johan G Bosch2, Lennart van Gils1

  • 1Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.

Ultrasound in Medicine & Biology
|May 14, 2019
PubMed

Insights

High frame rate ultrasound measures shear wave (SW) speed from heart valve closure. Faster SW speeds in hypertrophic cardiomyopathy (HCM) patients show potential for diagnosing heart conditions.

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Ultrasound
  • Myocardial Mechanics

Background:

  • Tissue Doppler imaging (TDI) is a standard echocardiographic technique.
  • Shear wave (SW) propagation in tissue can provide mechanical information.
  • Assessing myocardial stiffness non-invasively is clinically important.

Purpose of the Study:

  • To evaluate the clinical relevance of measuring naturally occurring shear wave (SW) velocities.
  • To differentiate normal myocardium from hypertrophic cardiomyopathy (HCM) using SW velocity.

Main Methods:

  • High frame rate (over 500 Hz) tissue Doppler ultrasound was used.
  • Shear wave (SW) velocities were measured during aortic and mitral valve closure.
  • 45 healthy volunteers and 43 HCM patients were included.

Main Results:

  • Mitral SW velocity (4.68 m/s) was faster than aortic SW velocity (3.51 m/s) in volunteers.
  • In HCM patients, SW velocities correlated with the E/e' ratio.
  • A threshold of 4 m/s for aortic SW velocity achieved 95% sensitivity and 90% specificity for classifying pathologic myocardium.

Conclusions:

  • Naturally occurring shear waves (SW) generated by valve closure can be measured.
  • SW velocity differs significantly between healthy individuals and HCM patients.
  • This method shows potential for non-invasive assessment of myocardial disease.

Keywords:
Cardiac elastographyCardiac shear waveHigh frame rateTissue Doppler

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