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Related Experiment Video

Updated: Jan 25, 2026

Isolated Pancreatic Islet Treatment and Apoptosis Measurement
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Quercetin Enhances the Function and Reduces Apoptosis of Mouse Islets.

S S Kim1, H J Jang2, M Y Oh3

  • 1Department of Anesthesia and Pain Medicine, Ulsan University College of Medicine, Gangneung Asan Hospital, Gangneung, South Korea.

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Summary

Quercetin (QE) treatment improves mouse islet viability and function before transplantation by reducing oxidative stress and apoptosis. This antioxidant flavonoid enhances antioxidant gene expression, offering potential benefits for islet transplantation success.

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Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Background:

  • Quercetin (QE) is a potent antioxidant and anti-inflammatory flavonoid.
  • Islets possess limited antioxidant capacity, making them vulnerable to oxidative stress.
  • Investigating QE's potential to enhance islet function prior to transplantation.

Purpose of the Study:

  • To determine if quercetin treatment can improve the function and viability of mouse islets.
  • To assess the effects of QE on oxidative stress markers and apoptosis in islets.
  • To evaluate QE's impact on antioxidant gene expression in islets.

Main Methods:

  • Balb/c mouse islets were treated with varying QE concentrations.
  • Islet viability, function, nitric oxide (NO), and inducible NO synthase (iNOS) expression were assessed.
  • Antioxidant gene expression, apoptosis, and related gene expression were analyzed in islets and INS-1 cells.

Main Results:

  • QE-treated islets and INS-1 cells exhibited enhanced function compared to controls.
  • QE treatment upregulated antioxidant genes (heme oxygenase-1, manganese-dependent superoxide dismutase, Bcl-2).
  • QE reduced NO, iNOS, and pro-apoptotic protein expression, mitigating oxidative stress and apoptosis.

Conclusions:

  • Quercetin enhances the viability of mouse islets.
  • QE treatment reduces apoptosis in islets, improving their resilience.
  • Quercetin improves islet function, suggesting potential for enhanced transplantation outcomes.