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Updated: Jan 25, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
The Role of Reactive Oxygen Species in In Vitro Cardiac Maturation
Nima Momtahan1, Cody O Crosby1, Janet Zoldan1
1Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78751, USA.
Abstract:
Recent advances in developmental biology and biomedical engineering have significantly improved the efficiency and purity of cardiomyocytes (CMs) generated from pluripotent stem cells (PSCs). Regardless of the protocol used to derive CMs, these cells exhibit hallmarks of functional immaturity. In this Opinion, we focus on reactive oxygen species (ROS), signaling molecules that can potentially modulate cardiac maturation. We outline how ROS impacts nearly every aspect associated with cardiac maturation, including contractility, calcium handling, metabolism, and hypertrophy. Though the precise role of ROS in cardiac maturation has yet to be elucidated, ROS may provide a valuable perspective for understanding the molecular mechanisms for cardiac maturation under various conditions.
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