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Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
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Cingulate Cortex Atrophy Is Associated With Hearing Loss in Presbycusis With Cochlear Amplifier Dysfunction.

Chama Belkhiria1,2, Rodrigo C Vergara1,2, Simón San Martín1,2

  • 1Department of Neuroscience, Faculty of Medicine, University of Chile, Santiago, Chile.

Frontiers in Aging Neuroscience
|May 14, 2019
PubMed
Summary

Age-related hearing loss (presbycusis) linked to cochlear amplifier dysfunction may cause brain atrophy and cognitive decline. This hearing impairment affects memory, language, and visual-spatial skills.

Keywords:
cochlear amplifiercognitiondementianeurodegenerationpresbycusis

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Area of Science:

  • Neuroscience
  • Audiology
  • Gerontology

Background:

  • Age-related hearing loss (presbycusis) is linked to cognitive decline and dementia risk.
  • Mechanisms connecting hearing loss to cognitive impairment are not fully understood.

Purpose of the Study:

  • To investigate the association between cochlear amplifier dysfunction and structural brain changes in older adults.
  • To explore the relationship between cochlear amplifier function, brain atrophy, and cognitive performance.

Main Methods:

  • 96 adults over 65 underwent brain MRI, neuropsychological tests, and audiological assessments.
  • Distortion product otoacoustic emissions measured cochlear amplifier function.
  • Analyses adjusted for age, gender, and education.

Main Results:

  • Cochlear amplifier dysfunction correlated with greater brain atrophy in the cingulate cortex and parahippocampus.
  • Cingulate cortex atrophy was associated with impairments in memory, language, and visuoconstruction.
  • Neural abnormalities extended beyond auditory networks.

Conclusions:

  • Cochlear amplifier dysfunction in presbycusis is linked to widespread brain atrophy.
  • This dysfunction is a significant mechanism connecting hearing loss to cognitive decline in multiple domains.
  • Findings suggest hearing health is crucial for maintaining cognitive function in aging.