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CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
Chloé Sauzay1,2, Konstantinos Voutetakis3,4, Aristotelis Chatziioannou3,5
1INSERM U1242, Proteostasis and Cancer Team, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1, Rennes, France.
Frontiers in Cell and Developmental Biology
|May 14, 2019
Summary
CD90, a protein found in T cells and neurons, is increasingly linked to cancer. This review explores CD90
Area of Science:
- Molecular biology
- Immunology
- Cancer research
Background:
- CD90 is a GPI-anchored protein with an Ig V-type superfamily domain.
- Initially identified in mouse T cells, CD90 is also expressed in neurons and fibroblasts.
- Emerging evidence suggests CD90 plays a role in cancer development.
Purpose of the Study:
- To review CD90 gene, mRNA, and protein characteristics.
- To summarize established associations between CD90 and cancer.
- To explore novel connections between CD90 and endoplasmic reticulum (ER) stress signaling in cancer.
Main Methods:
- Literature review of CD90.
- Analysis of CD90 expression in normal and cancerous tissues.
- Review of studies on ER stress signaling pathways.
Main Results:
- CD90 exhibits diverse expression patterns and functions in normal tissues.
- Significant links between CD90 expression/function and various cancers are documented.
- New functional interactions between CD90 and ER stress signaling are identified.
Conclusions:
- CD90's role in cancer is multifaceted and warrants further investigation.
- The interplay between CD90 and ER stress may represent a novel therapeutic target in oncology.
- Understanding CD90's functions can advance cancer biology and treatment strategies.
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