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CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule

Chloé Sauzay1,2, Konstantinos Voutetakis3,4, Aristotelis Chatziioannou3,5

  • 1INSERM U1242, Proteostasis and Cancer Team, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1, Rennes, France.

Frontiers in Cell and Developmental Biology
|May 14, 2019
PubMed

Insights

CD90, a protein found in T cells and neurons, is increasingly linked to cancer. This review explores CD90

Area of Science:

  • Molecular biology
  • Immunology
  • Cancer research

Background:

  • CD90 is a GPI-anchored protein with an Ig V-type superfamily domain.
  • Initially identified in mouse T cells, CD90 is also expressed in neurons and fibroblasts.
  • Emerging evidence suggests CD90 plays a role in cancer development.

Purpose of the Study:

  • To review CD90 gene, mRNA, and protein characteristics.
  • To summarize established associations between CD90 and cancer.
  • To explore novel connections between CD90 and endoplasmic reticulum (ER) stress signaling in cancer.

Main Methods:

  • Literature review of CD90.
  • Analysis of CD90 expression in normal and cancerous tissues.
  • Review of studies on ER stress signaling pathways.

Main Results:

  • CD90 exhibits diverse expression patterns and functions in normal tissues.
  • Significant links between CD90 expression/function and various cancers are documented.
  • New functional interactions between CD90 and ER stress signaling are identified.

Conclusions:

  • CD90's role in cancer is multifaceted and warrants further investigation.
  • The interplay between CD90 and ER stress may represent a novel therapeutic target in oncology.
  • Understanding CD90's functions can advance cancer biology and treatment strategies.
Keywords:
CD90ER stressIRE1THY-1cancerinvasionmigration

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