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Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3
Bernadette P Marriott1, Travis H Turner2, Joseph R Hibbeln3
1Nutrition Section, Division of Gastroenterology and Hepatology, Department of Medicine, and Military Division, Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Ste. 630D, MSC774, Charleston, SC, 29425, USA.
Contemporary Clinical Trials Communications
|May 14, 2019
Summary
This study investigated if krill oil, rich in omega-3 highly unsaturated fatty acids (HUFAs), improves cognitive function in US Army soldiers undergoing intense training. Results will inform the role of omega-3 HUFAs in military performance.
Area of Science:
- Neuroscience and Nutritional Science
- Military Medicine and Performance Optimization
Background:
- Omega-3 highly unsaturated fatty acids (HUFAs), particularly EPA and DHA, are vital for neuronal function, cognitive health, and mental well-being.
- Dietary intake of omega-3 HUFAs is crucial as they are essential nutrients not synthesized by the body.
- Krill oil is a dietary source of omega-3 HUFAs, differing in properties from other sources like fish oil.
Purpose of the Study:
- To evaluate the efficacy of krill oil supplementation in enhancing cognitive functions critical for military performance.
- To assess the impact of omega-3 HUFAs from krill oil on cognitive functioning immediately following intense combat simulation.
- To examine potential improvements in basic military training performance (IBOLC).
Main Methods:
- The Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3) study employed a double-blind, randomized, controlled trial design.
- Participants included US Army soldiers in the Infantry Basic Officer Leaders Course (IBOLC) and Ranger School training (RC).
- Intervention involved supplementation with omega-3 HUFA krill oil compared to a placebo.
Main Results:
- The study design and methods for the RRIPP-3 trial are presented.
- Cognitive functioning post-combat simulation and IBOLC performance were primary outcome measures.
- Dietary intake and other supplement use were recorded for comprehensive result interpretation.
Conclusions:
- The RRIPP-3 study provides a robust methodology to investigate the cognitive benefits of krill oil in a demanding military context.
- Findings will elucidate the role of omega-3 HUFAs in supporting cognitive resilience and performance under stress.
- The study contributes to understanding nutritional strategies for enhancing military readiness and operational effectiveness.