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Surrogate Model Development for Digital Experiments in Welding

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Chloroform as a CO surrogate: applications and recent developments.

Krishanu Mondal¹, Pallabi Halder, Greeshma Gopalan

¹Department of Applied Chemistry, IIT(ISM) Dhanbad, Dhanbad 826004, India. partha@iitism.ac.in.

Organic & Biomolecular Chemistry

|May 14, 2019

Summary

Chloroform offers a safer and more efficient alternative to carbon monoxide gas for synthesizing carbonyl compounds. This review highlights chloroform

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Area of Science:

Organic Synthesis
Medicinal Chemistry
Materials Chemistry

Background:

Carbonyl compounds are essential in organic synthesis, medicinal chemistry, and materials science.
Direct carbonylation using carbon monoxide (CO) gas presents safety hazards due to its toxicity and explosive nature.
Developing safe and efficient CO surrogates is crucial for modern synthetic chemistry.

Purpose of the Study:

To review the advantages of using chloroform as a carbon monoxide (CO) surrogate.
To survey recent carbonylation reactions employing chloroform as a CO source.

Main Methods:

Literature review of carbonylation reactions.
Analysis of chloroform's efficacy as a CO surrogate.

Main Results:

Chloroform provides a viable and safer alternative to CO gas for carbonylation reactions.
Recent studies demonstrate successful carbonylation using chloroform as the CO source.

Conclusions:

Chloroform is an advantageous and effective surrogate for CO in organic synthesis.
Its use simplifies the generation of carbonyl compounds, enhancing safety and efficiency.