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Updated: Jan 25, 2026
06:56
Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
Published on: January 7, 2021
2.8K
Fetal whole-heart 4D imaging using motion-corrected multi-planar real-time MRI
Joshua F P van Amerom1, David F A Lloyd1,2, Maria Deprez1
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom.
Magnetic Resonance in Medicine
|May 14, 2019
Summary
This study presents a new MRI method for clear 4D fetal heart imaging, overcoming motion challenges. This advanced visualization aids in comprehensive fetal cardiac assessment.
Area of Science:
- Medical Imaging
- Cardiovascular Imaging
- Fetal Medicine
Background:
- Maternal and fetal motion significantly challenge fetal heart MRI.
- Accurate visualization of the fetal heart and great vessels is crucial for prenatal diagnosis.
Purpose of the Study:
- To develop an MRI framework for volumetric cine visualization of the fetal heart and great vessels.
- To address challenges posed by maternal and fetal motion during imaging.
Main Methods:
- Utilized a highly-accelerated multi-planar real-time balanced steady-state free precession acquisition.
- Employed retrospective image-domain techniques for motion correction, cardiac synchronization, and outlier rejection.
- Validated the framework with a numerical phantom and evaluated in 20 fetal subjects (23-33 weeks gestational age).
Main Results:
- Achieved four-dimensional (4D) depiction of the fetal heart and great vessels.
- Reconstructed 4D data allowed visualization in any 2D plane, independent of scan plane prescription.
- The framework demonstrated robustness in fetal data and simulations, reliably recovering spatial and temporal features.
- Reconstruction was automated, requiring only user-specified masks.
Conclusions:
- The developed MRI framework shows promise for motion-compensated 4D assessment of the fetal heart and great vessels.
- This technique has the potential to serve as an adjunct to ultrasound or complement other MRI methods for comprehensive fetal cardiac evaluation.
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