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Self-Assembly of Metallo-Nucleoside Hydrogels for Injectable Materials That Promote Wound Closure.

Qian Tang1, Taylor N Plank2, Tong Zhu1

  • 1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering , East China Normal University , 500 Dongchuan Road , Shanghai 200241 , P. R. China.

ACS Applied Materials & Interfaces
|May 14, 2019
PubMed
Summary

Researchers developed a novel supramolecular hydrogel using cytidine, boric acid, and silver nitrate. This injectable material exhibits antibacterial properties and can be 3D printed for wound healing applications.

Keywords:
medical patchmetallo-nucleosideself-assemblysupramolecular hydrogelwound healing

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Supramolecular Chemistry

Background:

  • Injectable hydrogels are crucial scaffolds for tissue engineering and wound healing.
  • Current hydrogels primarily rely on polymers, with limited examples from low-molecular-weight gelators.
  • Developing novel self-assembling hydrogels is essential for advanced biomedical applications.

Purpose of the Study:

  • To synthesize and characterize a novel supramolecular hydrogel using cytidine and silver nitrate.
  • To investigate the structural basis and properties of the self-assembled hydrogel.
  • To evaluate the hydrogel's potential in tissue engineering, wound healing, and 3D printing.

Main Methods:

  • Room-temperature synthesis by mixing cytidine, boric acid (B(OH)3), and silver nitrate (AgNO3).
  • Structural analysis of the supramolecular hydrogel (C-B-C·Ag+).
  • Characterization of hydrogel properties including water content, stability, mechanical properties, and stimuli-responsiveness.

Main Results:

  • A stable, self-supporting supramolecular hydrogel (C-B-C·Ag+) was synthesized at room temperature.
  • The hydrogel exhibits high water content (>99.6%), mechanical stability (up to 10^4 Pa), and resistance to degradation.
  • Incorporation of silver ions (Ag+) provided significant antibacterial activity.
  • The hydrogel demonstrated shear-thinning behavior, enabling 3D printing of a medical patch.
  • The hydrogel promoted burn wound closure in a mouse model.

Conclusions:

  • The C-B-C·Ag+ hydrogel represents a novel class of injectable, self-assembling soft materials.
  • Its unique properties, including antibacterial activity and 3D printability, make it promising for wound healing and regenerative medicine.
  • This study highlights the potential of supramolecular chemistry in creating advanced functional biomaterials.