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Implementation of the FLORET UTE sequence for lung imaging.

Matthew M Willmering1, Ryan K Robison2, Hui Wang1,3

  • 1Center for Pulmonary Imaging Research, Divisions of Pulmonary Medicine and Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Magnetic Resonance in Medicine
|May 14, 2019
PubMed
Summary

The new FLORET spiral sequence enables faster, high-quality lung MRI scans. This advanced technique provides diagnostic-quality images comparable to traditional methods, even for conditions like cystic fibrosis.

Keywords:
FLORETUTEcystic fibrosislungnon-Cartesianspiral

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Area of Science:

  • Medical Imaging
  • Pulmonary Medicine
  • Biophysics

Background:

  • Lung MRI is challenging due to motion and short T2*.
  • Ultra-short echo time (UTE) sequences improve lung imaging.
  • Spiral UTE sequences offer potential k-space efficiency advantages.

Purpose of the Study:

  • To evaluate the novel FLORET (Fermat looped, orthogonally encoded trajectories) spiral 3D-UTE sequence for human lung MRI.
  • To compare FLORET performance against traditional radial UTE sequences.
  • To assess FLORET's utility in imaging both healthy and diseased lungs, including cystic fibrosis.

Main Methods:

  • FLORET sequence implemented and optimized for lung imaging.
  • Acquisition of radial UTE (3D and 2D) images for comparison in healthy subjects.
  • Quantitative analysis of SNR, vasculature contrast, diaphragm sharpness, and parenchymal density.

Main Results:

  • FLORET achieved comparable image quality to radial UTE methods.
  • FLORET significantly reduced scan time (1:55) versus 3D-radial (3:25) and 2D-radial (7:22).
  • FLORET demonstrated similar or superior visualization of cystic fibrosis lung pathology.

Conclusions:

  • FLORET enables faster acquisition of diagnostic-quality lung MRI.
  • The sequence effectively images short T2* lung components without compromising SNR or image quality.
  • FLORET shows promise for improved lung imaging and disease quantification.