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Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
Published on: June 14, 2024
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Neutralizing antibodies for HIV-1 prevention
Boris Julg1,2, Dan H Barouch1,2
1Ragon Institute of MGH, MIT and Harvard, Cambridge.
Current Opinion in HIV and AIDS
|May 15, 2019
Summary
Broadly neutralizing antibodies (bNAbs) show promise for HIV-1 prevention. Preclinical and clinical studies demonstrate their safety and efficacy, with ongoing research to confirm their role in preventing HIV-1 acquisition.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- HIV-1 prevention lacks a protective vaccine.
- Passive immunization with broadly neutralizing antibodies (bNAbs) is a promising alternative.
Purpose of the Study:
- To review preclinical and clinical studies of bNAbs for HIV-1 prevention.
- To discuss strategies for optimizing bNAb efficacy.
- To outline development pathways for bNAbs as prophylaxis.
Main Methods:
- Review of preclinical animal models.
- Analysis of clinical trial data for bNAbs.
- Evaluation of bNAb safety and antiviral activity.
Main Results:
- Second-generation bNAbs provide potent protection in preclinical models.
- Clinical evaluations show favorable safety and antiviral activity.
- Combinations of bNAbs may be necessary for broad HIV-1 coverage.
Conclusions:
- Encouraging preclinical and clinical data support bNAb development for HIV-1 prevention.
- Further optimization of viral coverage and antibody half-life is needed.
- bNAbs represent a critical future tool for HIV-1 prevention strategies.
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