Optimizing the Host in Fracture Surgery
Related Experiment Video
Updated: Jan 25, 2026

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents
Published on: August 14, 2018
Patrick F Bergin1, Ivan S Tarkin2, Lawrence B Kempton3
1Department of Orthopaedic Surgery, University of Mississippi Medical Center, Jackson, MS.
Abstract:
Multiple factors impact fracture healing; thus, endocrine optimization and nutritional optimization warrant investigation in the acute fracture and nonunion patient. This article presents current evidence regarding the role of the endocrinologists and the dietician in the fracture patient as well as the most recent data assessing the vitamin D axis in these populations. Similarly, the most recent information regarding the use and risks of NSAIDs in fracture healing are presented. The fracture surgeon must consider each individual patient and weigh the benefits versus the costs of host optimization.
Related Concept Videos
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Optimal Foraging
Optimization Problems
Optimal Arousal Theory
Inverted U-Shaped Performance Curve
The...
Unrealistic Optimism Bias
Optimizing Chromatographic Separations
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...

