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Oceans as a Source of Immunotherapy.

Bilal Ahmad1, Masaud Shah2, Sangdun Choi3

  • 1Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea. bilalpharma77@gmail.com.

Marine Drugs
|May 15, 2019
PubMed
Summary
This summary is machine-generated.

Marine flora yields unique bioactive compounds with potential for novel immunomodulators and biopharmaceuticals. This review explores their mechanisms and commercial applications for treating immune-mediated and other diseases.

Keywords:
Toll-like receptorimmunotherapyinflammationmarine drugmarine flora

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Area of Science:

  • Marine Biology
  • Pharmacology
  • Biochemistry

Background:

  • Marine flora represents a rich source of unique chemical compounds.
  • These compounds exhibit significant biological activity, offering potential for biopharmaceutical development.
  • Existing immunotherapies are limited, necessitating the search for novel treatments for immune-mediated diseases.

Purpose of the Study:

  • To review marine-originated bioactive molecules with immunomodulatory potential.
  • To focus on the molecular mechanisms and specific targets of these agents.
  • To address the commercial utilization of these compounds for drug improvement.

Main Methods:

  • Literature review of marine bioactive compounds.
  • Analysis of studies on immunomodulatory effects and molecular mechanisms.
  • Exploration of metabolic engineering and genomics for drug development.

Main Results:

  • Marine molecules demonstrate inhibitory activities in cellular processes like apoptosis and angiogenesis.
  • Specific marine compounds show therapeutic potential for various diseases, including cancer, inflammation, and microbial infections.
  • The review highlights the potential of marine-derived compounds as immunomodulators.

Conclusions:

  • Marine flora is a promising source for discovering novel biopharmaceuticals, particularly immunomodulators.
  • Understanding molecular mechanisms is key to developing effective marine-derived drugs.
  • Metabolic engineering and genomics offer pathways for commercializing these compounds.