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Updated: Jan 25, 2026

DNA Methylation: Bisulphite Modification and Analysis
Published on: October 21, 2011
DNA methylation modifications induced by hexavalent chromium
Xinnian Guo1, Lingfang Feng1, Bernardo Lemos2
1a Institute of Occupation Diseases, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P.R. China.
Abstract:
Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.
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