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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Trial and Error and Algorithm01:12

Trial and Error and Algorithm

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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

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Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
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Uncertainty in Measurement: Accuracy and Precision03:37

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
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Updated: Jan 25, 2026

Sampling and Analysis of Animal Scent Signals
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Sampling and Analysis of Animal Scent Signals

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SCENT Trial.

Philip M Meyers1, Alexander L Coon1, Peter T Kan1

  • 1From the Departments of Radiology and Neurological Surgery, Columbia University, New York, NY (P.M.M.).

Stroke
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

The Surpass Flow Diverter effectively treats large or giant wide-neck brain aneurysms, demonstrating favorable safety and efficacy outcomes at one year. This study confirms its potential in managing complex intracranial vascular conditions.

Keywords:
cerebrovascular disordersendovascular proceduresintracranial aneurysmstroke

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Area of Science:

  • Neurosurgery
  • Interventional Neuroradiology
  • Medical Devices

Background:

  • Large or giant wide-neck intracranial aneurysms pose significant treatment challenges.
  • Existing treatment modalities may have limitations in safety and efficacy for these complex cases.

Purpose of the Study:

  • To evaluate the safety and effectiveness of the Surpass Flow Diverter for treating large or giant wide-neck intracranial aneurysms.
  • To compare the outcomes of Surpass Flow Diverter treatment against historical safety and efficacy benchmarks.

Main Methods:

  • The SCENT trial was a prospective, single-arm, multicenter study involving 180 patients with intracranial aneurysms.
  • Patients received treatment with the Surpass Flow Diverter for wide-neck aneurysms (≥4 mm) that were large or giant (≥10 mm).
  • Primary endpoints assessed complete aneurysm occlusion, parent artery stenosis, retreatment, and major ipsilateral stroke or neurological death at 12 months.

Main Results:

  • The Surpass Flow Diverter was successfully implanted in 97.8% of patients.
  • The 12-month primary effectiveness rate, including complete occlusion, was 62.8%.
  • The 12-month primary safety endpoint of major ipsilateral stroke or neurological death was 8.3%.

Conclusions:

  • The Surpass Flow Diverter is a safe and effective treatment option for large or giant, wide-neck intracranial aneurysms.
  • The device meets or exceeds established performance goals for this challenging patient population.