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Updated: Jan 25, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
PET/Computed Tomography in Chronic Lymphocytic Leukemia and Richter Transformation
Joanna M Rhodes1, Anthony R Mato2
1Division of Hematology and Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Abstract:
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the United States. In 1-10% of cases, it can undergo Richter's transformation (RT) to either diffuse large B cell lymphoma (DLBCL) or Hodgkin's lymphoma (HL). Diagnosis requires histologic confirmation by tissue biopsy. PET/CT has been studied to in several series to look at its predictive value for identifying RT in biopsies. in this review, we will discuss the role of PET/CT to identify RT in patients CLL and its utility in clinical practice.
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