PET-Computed Tomography in Myeloma: Current Overview and Future Directions
Deepu Madduri1, Bart Barlogie1
1Mount Sinai Hospital/Tisch Cancer Institute, 1 Gustave L Levy Place, Box 1185, New York, NY 10029, USA.
PET Clinics
|May 16, 2019
Summary
The evolving treatment of multiple myeloma (MM) necessitates advanced imaging. Whole body skeletal surveys are crucial for assessing bone disease extent, complementing protein and bone marrow exams.
Area of Science:
- Oncology
- Radiology
- Hematology
Background:
- The multiple myeloma (MM) treatment landscape is rapidly advancing, improving patient survival.
- Current response criteria and imaging modalities need enhancement to accurately measure treatment effectiveness.
- Most MM patients have focal bone lesions not detected by standard myeloma protein and bone marrow examinations.
Purpose of the Study:
- To highlight the importance of advanced imaging in assessing treatment response in multiple myeloma.
- To emphasize the role of whole body skeletal surveys in evaluating the extent of bone disease at diagnosis.
Main Methods:
- Review of current literature on multiple myeloma treatment response assessment.
- Discussion of the utility of whole body skeletal surveys in clinical practice.
Main Results:
- Whole body skeletal survey is the established standard for determining the extent of myeloma bone disease at initial diagnosis.
- Effective treatment strategies in MM require robust methods for measuring response beyond serological markers.
Conclusions:
- Accurate assessment of bone disease extent via imaging is critical for effective multiple myeloma management.
- Further development of imaging modalities is needed to complement existing response criteria for MM.
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