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Long-term outcomes of very low birth weight infants with spontaneous intestinal perforation: A retrospective

Isabelle Adant1, Marc Miserez2, Gunnar Naulaers3

  • 1Department of Pediatrics, University Hospitals Leuven, Belgium Herestraat 49, B-3000 Leuven, Belgium.

Journal of Pediatric Surgery
|May 16, 2019
PubMed

Insights

Spontaneous intestinal perforation (SIP) survivors face higher risks of multiple disabilities. However, quality of life and gastrointestinal outcomes were similar to controls, with intraventricular hemorrhage impacting neurodevelopment.

Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Developmental Pediatrics

Background:

  • Spontaneous intestinal perforation (SIP) is a severe complication in extremely premature infants.
  • Long-term outcomes for SIP survivors require further investigation.

Purpose of the Study:

  • To compare neurodevelopmental, gastrointestinal, and quality of life outcomes in SIP survivors versus matched controls.
  • To identify factors influencing neurodevelopmental outcomes in this cohort.

Main Methods:

  • Retrospective case-matched cohort study of infants treated for SIP.
  • Matched controls based on gestational age, gender, and birth period.
  • Evaluated outcomes via medical records review and telephone surveys (PedsQL™ 4.0).

Main Results:

  • SIP survivors had significantly higher rates of multiple disabilities (40% vs. 17%) and physiotherapy needs (86% vs. 60%).
  • Intraventricular hemorrhage (IVH) was a strong predictor of worse neurodevelopmental outcomes (OR=8.79).
  • Female gender showed a protective effect against disability (OR=0.06); quality of life and GI comorbidities did not differ.

Conclusions:

  • SIP survivors are at increased risk for multiple disabilities.
  • IVH and female gender significantly influence neurodevelopmental outcomes, independent of SIP.
Abstract

Keywords:
Neurodevelopmental outcomePretermQuality of lifeSpontaneous intestinal perforationVery low birthweight infant

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