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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease

Sara Torretta1,2, Lorenzo Drago3,4, Paola Marchisio5,6

  • 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, Italy. sara.torretta@unimi.it.

Journal of Clinical Medicine
|May 16, 2019
PubMed

Insights

Bacterial biofilms may explain why antibiotics fail for chronic adenoiditis in children, potentially leading to chronic middle ear infections and hearing issues. This review explores biofilm involvement in these conditions.

Area of Science:

  • Pediatric Otolaryngology
  • Microbiology
  • Infectious Diseases

Background:

  • Chronic adenoiditis is common in children and often leads to recurrent or chronic middle ear diseases.
  • These conditions can cause long-term hearing impairment and functional sequelae.
  • Surgical intervention is common for children unresponsive to antibiotic therapy.

Purpose of the Study:

  • To review current evidence on the role of bacterial biofilms in chronic adenoiditis.
  • To investigate the link between biofilms, chronic adenoiditis, and associated middle ear infections in children.

Main Methods:

  • Literature review of existing studies on bacterial biofilms.
  • Analysis of research concerning chronic adenoiditis and pediatric middle ear infections.
  • Synthesis of evidence linking nasopharyngeal biofilms to disease development.

Main Results:

  • Antibiotic treatment failure in chronic adenoiditis may be linked to nasopharyngeal bacterial biofilms.
  • Biofilms are implicated in the development of chronic nasopharyngeal inflammation.
  • These biofilms may contribute to the occurrence of chronic or recurrent middle ear disease.

Conclusions:

  • Bacterial biofilms are a significant factor in the pathogenesis of chronic adenoiditis.
  • Understanding biofilm involvement could lead to improved treatment strategies for pediatric adenoiditis and middle ear infections.
  • Further research into biofilm-based therapies is warranted for affected children.

Keywords:
Biofilmadenoidsnasopharynxotitisupper respiratory tract infections

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