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Evaluation of thyroid dysfunction in patients with nephrotic syndrome
Deepak Jain1, Hari Krishan Aggarwal1, Y M Pavan Kumar2
1Department of Medicine and Division of Nephrology, Pt. B.D. Sharma University of Health Sciences, Rohtak (Haryana), India.
Medicine and Pharmacy Reports
|May 16, 2019
Summary
Thyroid dysfunction is common in patients with nephrotic range proteinuria. Thyroid autoimmunity exacerbates this condition, leading to increased proteinuria and elevated TSH levels, suggesting a significant link between these conditions.
Area of Science:
- Nephrology
- Endocrinology
- Immunology
Background:
- Thyroid and kidney function are interdependent.
- Proteinuria can lead to urinary loss of thyroid hormones, potentially causing hypothyroidism.
- Autoimmune conditions can simultaneously affect both the thyroid and kidneys.
Purpose of the Study:
- To investigate the impact of proteinuria on thyroid function.
- To explore the association between proteinuria and thyroid autoimmunity.
Main Methods:
- Studied 60 patients with nephrotic range proteinuria.
- Assessed thyroid profile, Anti-TPO antibodies, and renal biopsy.
- Grouped patients based on Anti-TPO antibody status (positive vs. negative).
Main Results:
- Anti-TPO positive patients showed significantly higher TSH, proteinuria, and serum creatinine levels.
- These patients also had lower estimated glomerular filtration rate (eGFR) and serum albumin.
- TSH levels strongly correlated with proteinuria, serum creatinine, serum albumin, and eGFR.
Conclusions:
- Nephrotic range proteinuria commonly causes thyroid dysfunction, with autoimmunity intensifying the effects.
- A significant correlation exists between thyroid autoimmunity and nephrotic syndrome.
- High suspicion for thyroid antibodies is warranted in nephrotic syndrome patients.
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