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Updated: Jan 24, 2026
08:36
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
8.5K
Cortical thickness, white matter hyperintensities, and cognition after stroke
David Alexander Dickie1, Kirstyn Gardner1, Annika Wagener1,2
1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.
Summary
In stroke patients, a thinner cerebral cortex correlates with more white matter hyperintensities, but cortical thickness does not independently predict cognitive function. Further research is needed to understand this relationship in stroke survivors.
Area of Science:
- Neurology
- Neuroimaging
- Cerebrovascular Disease
Background:
- A thinner cerebral cortex is linked to cognitive impairment and increased white matter hyperintensity (WMH) burden in general populations.
- Assessing this association in ischemic stroke patients is crucial due to their distinct cerebrovascular disease profiles.
Purpose of the Study:
- To investigate the relationship between cortical thickness, WMH burden, and cognitive function in individuals following an ischemic stroke.
Main Methods:
- Cortical thickness was measured using advanced normalization tools in 244 ischemic stroke patients.
- White matter hyperintensity burden was quantified using Fazekas score and volumetric analysis.
- Cognitive function was assessed using the Mini Mental State Examination (MMSE) at one year, with statistical analyses including correlation and multiple linear regression.
Main Results:
- Higher WMH burden (Fazekas score) was significantly associated with thinner cortical thickness (rho = -0.284, P < 0.0001).
- Voxel-wise analyses revealed negative associations between cortical thickness and WMH in fronto-temporal and inferior parietal regions.
- While mean cortical thickness correlated positively with MMSE scores, this association was not independent of age and WMH burden.
Conclusions:
- Cortical thickness is not an independent predictor of cognition in ischemic stroke survivors.
- Further investigation is required to elucidate the mechanisms linking WMH to cortical thinning, particularly in specific brain regions affected by stroke.
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