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Plateletcrit: A possible biomarker of inflammation in hepatitis A infection

M E Coskun1, A Alidris1, M T Temel1

  • 1Department of Paediatrics, University of Gaziantep, Gaziantep, Turkey.

Nigerian Journal of Clinical Practice
|May 16, 2019
PubMed

Insights

Plateletcrit (PCT) and mean platelet volume (MPV) were elevated in children with Hepatitis A infection. PCT showed a negative correlation with liver inflammation markers, suggesting its role in assessing HepA severity.

Area of Science:

  • Hepatology
  • Hematology
  • Pediatric Infectious Diseases

Background:

  • Hepatitis A (HepA) is a global liver infection.
  • Platelet indices like plateletcrit (PCT) may indicate inflammation.

Purpose of the Study:

  • To investigate changes in PCT during acute HepA infection.
  • To assess PCT and MPV as markers of inflammation in HepA.

Main Methods:

  • Compared platelet indices (PCT, MPV) in 73 children with HepA and 68 healthy controls.
  • Analyzed complete blood counts using an XN-1000 analyzer.

Main Results:

  • Children with HepA had higher PCT and MPV than controls.
  • PCT and platelet counts negatively correlated with ALT, a liver inflammation marker.
  • MPV did not correlate with ALT levels.

Conclusions:

  • Both MPV and PCT reflect inflammation in acute HepA.
  • PCT correlates negatively with the degree of liver inflammation in HepA.
Abstract

Keywords:
Childrenhepatitis Ainflammationplateletcrit

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