Related Experiment Video
Updated: Jan 24, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Early predictors of continuous positive airway pressure failure in preterm neonates
Venkatakrishna Kakkilaya1, Sheron Wagner2, Kate Louise M Mangona3
1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Venkat.Kakkilaya@UTsouthwestern.edu.
Objective:
To develop a prediction model to identify infants admitted on continuous positive airway pressure (CPAP) requiring intubation within seventy-two hours of life (HOL).
Study Design:
Infants born ≤29 weeks' gestational age between 2013 and April 2018 were randomly assigned to either a modeling cohort (MC) or a validation cohort (VC) in a 2:1 ratio. Variables available within two HOL were compared between the CPAP failure group (CFG) and the CPAP success group (CSG).
Results:
Of the 189 infants in the MC, 50% failed CPAP. Compared to CSG, infants in the CFG had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (RDS) and fraction of inspired oxygen (FiO2). A forward stepwise logistic regression modeling in both MC and VC showed that FiO2 >0.3 and radiographic severe RDS predicted CPAP failure.
Conclusion:
FiO2 >0.3 within two HOL and radiographic severe RDS predicts CPAP failure in preterm infants.
More Related Videos
04:56Laryngeal Mask Airway LMA Placement in a Neonatal Patient Simulator Using a Non-Inflatable Supraglottic Airway SGA
Published on: July 14, 2023
08:58Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Related Concept Videos
Position-effect Variegation
Serial Position Effect
Continuing Care
Continuity Equation
The mass flow rate is expressed as:
Suctioning the Oropharyngeal Airway
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
Suctioning the Nasopharyngeal Airway
Equipment Required