Related Experiment Video

Updated: Jan 24, 2026

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors
08:50

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors

Published on: July 16, 2018

8.6K

Risk factors of mortality and recoarctation after coarctation repair in infancy

Amélia Lehnert1, Olivier Villemain1,2, Régis Gaudin1

  • 1M3C-Necker Enfants Malades, AP-HP, Paris, France.

Interactive Cardiovascular and Thoracic Surgery
|May 16, 2019
PubMed

Insights

Infants undergoing aortic coarctation (CoA) repair have good outcomes, but reintervention is sometimes needed. Early repair (under 15 days) and prostaglandin E1 (PGE1) use increase reintervention risk.

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Aortic coarctation (CoA) repair in infants presents challenges in achieving durable results without complications.
  • Predicting the need for reintervention is crucial for improving long-term outcomes in pediatric patients.

Purpose of the Study:

  • To identify predictors of aortic arch reintervention following surgical repair of aortic coarctation in infants.
  • To analyze factors influencing the need for repeat aortic arch procedures in this population.

Main Methods:

  • Retrospective analysis of 530 infants with isolated CoA or CoA with ventricular septal defect (VSD) undergoing aortic arch repair before 3 months of age.
  • Data collected between January 2000 and March 2014, with a median follow-up of 7.57 years.
  • Statistical analysis to determine risk factors for aortic arch reintervention.

Main Results:

  • 11.5% of patients required aortic arch reintervention, with freedom from reintervention at 5 years being 88.5%.
  • Risk factors for reintervention included repair at age <15 days and the intraoperative use of prostaglandin E1 (PGE1).
  • End-to-end repair in patients receiving PGE1 showed a higher risk of recoarctation compared to extended end-to-side repair.

Conclusions:

  • Aortic coarctation repair in young infants generally yields good outcomes.
  • The use of PGE1 may alter aortic arch anatomy, potentially complicating surgical resection and increasing reintervention risk.
  • Further research is needed to optimize preoperative management, particularly concerning PGE1 use.
Abstract

Keywords:
CoarctationCongenital heart diseaseOutcomePaediatricsSurgery

More Related Videos

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.6K
Preparation of Nucleosome Core Particles Complexed with DNA Repair Factors for Cryo-Electron Microscopy Structural Determination07:59

Preparation of Nucleosome Core Particles Complexed with DNA Repair Factors for Cryo-Electron Microscopy Structural Determination

Published on: August 17, 2022

2.3K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Socioemotional Development during Infancy01:30

Socioemotional Development during Infancy

Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
443
Mismatch Repair01:36

Mismatch Repair

Overview
43.6K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
7.9K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.5K
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.1K