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Updated: Jan 24, 2026

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration
Published on: February 10, 2023
Roles of hyaluronan in cardiovascular and nervous system disorders
Hong-Yan Ding1, Ya-Nan Xie1, Qiang Dong1
1Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Abstract:
Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.
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