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Asthma in children with sickle cell disease
Shaina M Willen1, Mark Rodeghier2, Michael R DeBaun3
1Division of Pulmonary Medicine, Department of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, California.
Current Opinion in Pediatrics
|May 16, 2019
Summary
Children with sickle cell disease (SCD) often show asthma-like symptoms. Further research is needed to understand if this is true asthma or a related lung condition in SCD patients.
Area of Science:
- Pediatric Pulmonology
- Hematology
- Allergy and Immunology
Background:
- Asthma is frequently observed in children with sickle cell disease (SCD), correlating with increased illness.
- Healthcare providers question whether asthma is a true comorbidity or an asthma-like phenotype in children with SCD.
Purpose of the Study:
- To review the current understanding of asthma in children with SCD.
- To differentiate between true asthma and asthma-like symptoms in this population.
Main Methods:
- Review of clinical signs and symptoms in children with SCD.
- Analysis of lung function and inflammatory markers.
Main Results:
- Children with SCD exhibit asthma-like symptoms such as wheezing, airway hyperresponsiveness, and abnormal lung function, regardless of an asthma diagnosis.
- These symptoms are present both in children with and without a formal asthma diagnosis.
Conclusions:
- Lung disease in children with SCD has significant implications, irrespective of its origin.
- Further research is essential for developing effective interventions to prevent complications in children with SCD and pulmonary issues.
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