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Updated: Jan 24, 2026

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
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Lung donation after circulatory death.

Laurens J Ceulemans1,2,3, Ilhan Inci3, Dirk Van Raemdonck1,2

  • 1Department of Thoracic Surgery, University Hospitals Leuven.

Current Opinion in Organ Transplantation
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

Donation after circulatory death (DCD) lung transplantation (LTx) shows promising results comparable to donation after brain death. Overcoming barriers to DCD utilization can increase lung availability for patients needing transplants.

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Area of Science:

  • Transplantation Medicine
  • Cardiopulmonary Surgery
  • Organ Donation

Background:

  • Increasing global demand for lung transplants.
  • Underutilization of lung donors after circulatory death (DCD).
  • Need for updated insights into DCD lung donation and transplantation.

Purpose of the Study:

  • To provide a concise review of current literature on DCD and lung transplantation (LTx).
  • To summarize experimental and clinical experiences with DCD lung donors.
  • To analyze barriers and advancements in DCD lung donation.

Main Methods:

  • Comprehensive literature review of published studies on DCD and LTx.
  • Analysis of experimental data and international clinical outcomes.
  • Examination of different DCD categories, focusing on DCD V.

Main Results:

  • Lung transplantation from DCD donors yields results comparable to donation after brain death.
  • Short-term and long-term outcomes are satisfactory, with considerations for chronic lung allograft dysfunction.
  • The DCD V category shows significant potential for increasing donor lung utilization.

Conclusions:

  • Barriers to DCD utilization in lung transplantation should be addressed.
  • Safe implementation of more DCD LTx programs is feasible and recommended.
  • Advancements like ex-vivo lung perfusion offer future potential for DCD lung utilization.