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Cutaneous collagenous vasculopathy: light and transmission electron microscopy
Debora Sarzi Sartori1,2, Hiram Larangeira de Almeida2,3, Timotio Volnei Dorn4
1Academic Hospital, Universidade Federal de Pelotas, Pelotas (RS), Brazil.
Anais Brasileiros De Dermatologia
|May 16, 2019
Summary
Cutaneous collagenous vasculopathy is a rare vascular disorder causing telangiectasias due to collagen buildup. Diagnosis involves clinical history and specific immunostaining confirming collagen IV accumulation.
Area of Science:
- Dermatology
- Vascular Biology
- Histopathology
Background:
- Cutaneous collagenous vasculopathy (CCV) is a rare acquired microangiopathy.
- It presents as progressive, asymptomatic telangiectasias.
- Histologically, CCV is defined by collagen type IV accumulation around dermal vessels.
Observation:
- A case report details a patient with extensive acquired telangiectasias on the left arm.
- The clinical presentation mimicked unilateral nevoid telangiectasia.
- Dermal examination revealed dilated blood vessels with thickened walls.
Findings:
- Immunohistochemistry confirmed significant collagen IV deposition around affected vessels.
- Transmission electron microscopy showed duplicated and triplicated vascular basal membranes.
- Amorphous material deposition was observed around these abnormal membranes.
Implications:
- This case highlights the diagnostic criteria for cutaneous collagenous vasculopathy.
- It underscores the importance of specialized microscopy and immunostaining for accurate diagnosis.
- Understanding the ultrastructural changes aids in characterizing this rare microangiopathy.
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