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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer

Rudy Mevizou1, Audrey Sirvent2, Serge Roche3

  • 1CRBM, CNRS, Univ. Montpellier, "Equipe labellisée Ligue Contre le Cancer", F-34000 Montpellier, France. rudy.mevizou@crbm.cnrs.fr.

Cancers
|May 17, 2019
PubMed

Insights

Small adaptor proteins like SLAP and SOCS regulate key signaling pathways in the intestine. Their loss of function may promote colorectal cancer (CRC) development, suggesting therapeutic potential.

Area of Science:

  • Molecular biology
  • Cancer research
  • Cell signaling

Background:

  • Tyrosine kinases (TKs) are crucial for intestinal cell communication and fate.
  • Aberrant TK activity is linked to carcinogenesis, but its role in colorectal cancer (CRC) is unclear.
  • Small adaptor proteins can regulate TK signaling and act as tumor suppressors.

Purpose of the Study:

  • To review the roles of SLAP and SOCS adaptor proteins in regulating SRC and JAK pathways.
  • To explore how loss of these adaptors in the intestinal epithelium influences tumor formation.
  • To discuss the potential therapeutic value of SLAP and SOCS in CRC.

Main Methods:

  • Literature review of studies on SLAP, SOCS, SRC, and JAK pathways.
  • Analysis of the impact of adaptor protein function on intestinal tumorigenesis.
  • Discussion of potential therapeutic strategies targeting these adaptors in CRC.

Main Results:

  • SLAP regulates SRC pathways, and SOCS regulates JAK pathways.
  • Loss of function of these adaptors in the intestinal epithelium may contribute to tumor formation.
  • These adaptors show potential as therapeutic targets in CRC.

Conclusions:

  • SLAP and SOCS adaptor proteins play significant roles in regulating oncogenic TK pathways.
  • Dysregulation of SLAP and SOCS in the intestinal epithelium is implicated in colorectal cancer development.
  • Targeting SLAP and SOCS offers a promising therapeutic avenue for CRC treatment.
Keywords:
cell signallingcolorectal cancersmall adaptor proteinstargeted therapytyrosine kinase

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