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Related Experiment Video

Updated: Jan 24, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
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Intratympanically Delivered Steroids Impact Thousands More Inner Ear Genes Than Systemic Delivery.

Dennis R Trune1, Katherine D Shives1,2, Fran Hausman1

  • 11 Oregon Hearing Research Center, Department of Otolaryngology-Head & Neck Surgery, OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.

The Annals of Otology, Rhinology, and Laryngology
|May 17, 2019
PubMed
Summary
This summary is machine-generated.

Steroids significantly alter inner ear gene expression, with intratympanic delivery impacting more genes than systemic administration. This suggests a broader molecular effect than previously understood for hearing loss treatments.

Keywords:
gene microarrayglucocorticoidinner earintratympanic steroidsmineralocorticoidsteroid therapy

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Area of Science:

  • Otolaryngology
  • Molecular Biology
  • Genomics

Background:

  • Glucocorticoids are used for sensorineural hearing loss, but their molecular effects on the inner ear are poorly understood.
  • Intratympanic steroid delivery is claimed to improve hearing recovery, yet molecular evidence is lacking.

Purpose of the Study:

  • To investigate the molecular impact of glucocorticoids and mineralocorticoids on the inner ear.
  • To compare the effects of systemic versus intratympanic steroid delivery on inner ear gene expression.

Main Methods:

  • Gene chip analysis (Affymetrix 430 2.0) was performed on mouse inner ears.
  • Mice received systemic or intratympanic administration of prednisolone, dexamethasone, or aldosterone.
  • Gene expression was analyzed 6 hours post-treatment and compared to controls.

Main Results:

  • Steroids altered the expression of 55% to 82% of approximately 17,500 normally expressed inner ear genes.
  • Intratympanic delivery significantly increased the number of affected genes compared to systemic delivery for all tested steroids.
  • Glucocorticoids impacted more genes via the mineralocorticoid receptor than the glucocorticoid receptor.

Conclusions:

  • Steroid treatment profoundly affects thousands of inner ear genes, with a greater impact via intratympanic delivery.
  • The influence of glucocorticoids on mineralocorticoid receptor pathways in the inner ear is more significant than previously recognized.
  • Current therapeutic strategies for hearing loss using steroids require reassessment due to their extensive molecular effects.