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Extensive burn injury causes bone collagen network alteration and growth delay related to RANK-L immunoexpression

Tabata De Carvalho Tomé1, Hananiah Tardivo Quintana1, Jeferson André Bortolin1

  • 1Departamento de Biociências, Universidade Federal de São Paulo, Campus Baixada Santista , SP, Brazil.

Connective Tissue Research
|May 17, 2019
PubMed

Insights

Extensive burn injury in young rats delayed bone growth and altered collagen structure. Increased RANK-L expression suggests enhanced bone resorption, contributing to growth impairment.

Area of Science:

  • Biomedical research
  • Skeletal biology
  • Burn injury consequences

Background:

  • Extensive burn injuries in children can cause hypermetabolism and growth delay.
  • Understanding the bone development impact is crucial for pediatric burn care.

Purpose of the Study:

  • To investigate bone histopathology and morphometrics in an experimental burn model.
  • To analyze collagen fiber networks and bone development markers post-burn.

Main Methods:

  • Wistar rats were divided into control and scald burn injury (SBI) groups.
  • Femur epiphyses were analyzed histologically, morphometrically, and for RUNX-2 and RANK-L expression.
  • Samples were collected 4 and 14 days post-injury.

Main Results:

  • SBI delayed secondary ossification center appearance and reduced epiphyseal plate thickness.
  • Collagen networks in articular cartilage were altered in SBI groups.
  • RANK-L expression was significantly higher in SBI rats compared to controls.

Conclusions:

  • Extensive burn injury leads to delayed bone growth and structural changes.
  • Altered collagen and increased RANK-L contribute to enhanced osteoclastogenesis and impaired bone development.
Abstract

Keywords:
collagenepiphyseal platefemurgrowthimmunohistochemistry

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