Related Experiment Video

Updated: Jan 24, 2026

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

14.3K

Correlation Between Uptake of 18F-FDG During PET/CT and Ki-67 Expression in Patients Newly Diagnosed With Multiple

Qian Li1,2,3, Jing Ma1,3, Han Li1

  • 11 Department of Hematology and Blood and Marrow Transplantation, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer. Tianjin's Clinical Research Center for Cancer. Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

Technology in Cancer Research & Treatment
|May 17, 2019
PubMed

Insights

Prognosis for multiple myeloma patients with extramedullary involvement (EMM) can be predicted. Elevated 18F-FDG uptake and Ki-67 expression in EMM correlate with poorer survival outcomes.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Pathology

Background:

  • Multiple myeloma (MM) is a hematologic malignancy.
  • Extramedullary involvement (EMM) in MM indicates a more aggressive disease course.
  • Predictive markers for MM prognosis are crucial for treatment planning.

Purpose of the Study:

  • To assess the prognostic value of 18F-FDG maximum standardized uptake value (SUVmax) and Ki-67 expression in patients with MM and EMM.
  • To determine the correlation between these markers and patient survival outcomes.

Main Methods:

  • Retrospective analysis of 20 newly diagnosed MM patients with EMM.
  • Evaluation of 18F-FDG PET/CT scans for SUVmax in EMM lesions.
  • Assessment of Ki-67 expression via immunohistochemistry in biopsy samples of EMM.
  • Correlation analysis with progression-free survival (PFS) and overall survival (OS).

Main Results:

  • Both 18F-FDG SUVmax and Ki-67 expression in EMM significantly correlated with PFS (P=.039 and P=.009, respectively).
  • Combined analysis of SUVmax and Ki-67 showed significant correlations with both OS (P=.027) and PFS (P=.014).
  • EMM detected at initial presentation is associated with poor patient outcomes.

Conclusions:

  • 18F-FDG SUVmax and Ki-67 expression are valuable prognostic indicators in MM patients with EMM.
  • These markers can aid in the accurate evaluation of prognosis for EMM patients.
  • Early detection of EMM warrants careful prognostic assessment and tailored management strategies.
Keywords:
Ki-67PET-CTextramedullary involvementmultiple myelomasurvival analysis

More Related Videos

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.2K
Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

3.5K

Related Concept Videos

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
25.8K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

3.9K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.3K
Correlations02:20

Correlations

Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Correlation and Causation01:27

Correlation and Causation

Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.4K
Diagnosing Acidosis and Alkalosis01:24

Diagnosing Acidosis and Alkalosis

Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2  and...
1.1K