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Updated: Jan 24, 2026

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices
Published on: October 3, 2016
Postapproval Monitoring Practices at Biomedical Research Facilities
Jennifer N Davis1, William Greer, Ron E Banks2
1Office of Animal Welfare, University of Pennsylvania, Philadelphia, Pennsylvania.
Abstract:
Federal regulations and policies require institutions to establish procedures for ongoing IACUC oversight of approved animal care and use program activities including animal procedures. To fulfill these requirements, research institutions implement postapproval monitoring (PAM) programs designed to assure compliance in animal activities. Although several references commenting on the requirement to conduct PAM are available, few publications discuss actual best practices for accomplishing PAM. Here we use information collected through a survey of large academic research institutions to identify common practices for conducting PAM reviews. Many similarities and differences exist between institutions, which may or may not influence the overall quality of an institution's PAM program.
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