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Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
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Using ordinal outcomes to construct and select biomarker combinations for single-level prediction.

Allison Meisner1, Chirag R Parikh2,3, Kathleen F Kerr4

  • 11Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.

Diagnostic and Prognostic Research
|May 17, 2019
PubMed
Summary

Sophisticated methods for biomarker combinations improve prediction of ordinal outcomes, like disease severity. Utilizing the outcome

Keywords:
BiomarkerCombinationsOrdinal

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Area of Science:

  • Biostatistics
  • Biomarker Discovery
  • Clinical Prediction Models

Background:

  • Biomarker studies often analyze ordinal outcomes (e.g., no, mild, severe disease).
  • Predicting a specific outcome level is frequently a key clinical objective.

Purpose of the Study:

  • To evaluate if advanced methods outperform simple binary logistic regression for ordinal outcomes.
  • To develop and assess an algorithm for selecting optimal biomarker combinations using ordinal outcome information.

Main Methods:

  • Compared sophisticated modeling approaches against binary logistic regression after outcome dichotomization.
  • Proposed and applied an algorithm leveraging ordinal outcome data for biomarker combination selection.
  • Utilized data from a study on acute kidney injury severity after cardiac surgery.

Main Results:

  • Advanced modeling techniques demonstrated advantages over the simple binary approach in certain scenarios.
  • The proposed algorithm reduced selection bias and enhanced the performance of selected biomarker combinations.
  • Improved predictive performance was observed when utilizing the ordinal nature of the outcome.

Conclusions:

  • Methods incorporating the ordinal nature of outcomes can lead to superior biomarker combinations.
  • Leveraging ordinal information in biomarker construction and selection offers significant potential for improved clinical utility.