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Related Experiment Video

Updated: Jan 24, 2026

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
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Whole-brain microcirculation detection after ischemic stroke based on swept-source optical coherence tomography.

Jian Liu1, Ning Ding2, Yao Yu1

  • 1School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China.

Journal of Biophotonics
|May 17, 2019
PubMed
Summary

This study monitored whole-brain microcirculation in rats with middle cerebral artery occlusion (MCAO) using swept-source OCT. Real-time cerebral perfusion tracking offers new insights into ischemic stroke mechanisms and treatment assessment.

Keywords:
constrained image registrationischemic strokeswept-source optical coherence tomographywide field of view

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Ischemic stroke is linked to cerebral blood flow, making real-time perfusion monitoring crucial for understanding disease mechanisms.
  • A wide field of view (FOV) is beneficial for capturing lesions and observing disease progression in stroke research.

Purpose of the Study:

  • To monitor whole-brain microcirculation in middle cerebral artery occlusion (MCAO) rat models over time using a wide FOV swept-source OCT (SS-OCT) system.
  • To quantify and compare cerebral perfusion levels in both hemispheres and the whole brain during ischemic conditions.

Main Methods:

  • Utilized a wide FOV swept-source OCT (SS-OCT) system for whole-brain microcirculation monitoring in MCAO rats.
  • Employed a constrained image registration algorithm to mitigate motion artifacts in wide FOV angiography.
  • Quantified cerebral perfusion levels and recorded changes in blood vessel shape and location during ischemia.

Main Results:

  • Demonstrated highly consistent trends in cerebral perfusion levels between the left and right hemispheres during MCAO.
  • Observed temporal variations in the position of blood vessels throughout the experiment.
  • Successfully quantified and compared perfusion across different brain regions.

Conclusions:

  • Real-time, wide FOV SS-OCT monitoring provides valuable insights into whole-brain microcirculation dynamics during ischemic stroke.
  • The findings support the utility of this technique for understanding stroke mechanisms and evaluating potential therapeutic interventions.