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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Stimulus-responsive polymeric nanogels as smart drug delivery systems
Sakineh Hajebi1, Navid Rabiee2, Mojtaba Bagherzadeh2
1Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Acta Biomaterialia
|May 17, 2019
Summary
Polymeric nanogels are versatile drug delivery systems. These smart nanoparticles offer controlled drug release in response to stimuli like pH and temperature, minimizing side effects.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Nanogels are nanoscale polymer networks with tunable properties, making them promising for drug delivery.
- Their biocompatibility, stability, and surface modifiability enable targeted drug delivery.
- Stimulus-responsive nanogels offer controlled drug release, reducing accumulation in non-target tissues.
Purpose of the Study:
- To introduce nanogels and their preparation methods.
- To review the design of stimulus-responsive nanogels for controlled drug release.
- To highlight the role of nanogels in advanced drug delivery vehicles.
Main Methods:
- Review of existing literature on nanogel preparation.
- Analysis of stimulus-responsive mechanisms (pH, temperature, light, redox).
- Discussion of surface modification for active targeting.
Main Results:
- Nanogels exhibit tunable particle size and high drug loading capacity.
- Stimulus-responsive nanogels provide controlled drug release upon specific triggers.
- Surface functionalization allows for targeted delivery to specific cells or tissues.
Conclusions:
- Polymeric nanogels are crucial for developing innovative drug delivery systems.
- Stimulus-responsive nanogels represent a significant advancement in "smart" drug delivery.
- Further research into nanogel design will enhance therapeutic efficacy and patient outcomes.
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