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Expression of circular RNAs in gynecological tumors: A systematic review

Kangsheng Liu1, Qin Zhang2, Feng Pan3

  • 1Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital.

Medicine
|May 18, 2019
PubMed
Abstract

Insights

Circular RNAs (ribonucleic acids) are key players in gynecological tumors. Research highlights their role in ovarian and cervical cancers, suggesting potential as biomarkers and therapeutic targets.

Area of Science:

  • Bioinformatics and molecular biology
  • Genomics and transcriptomics
  • Oncology and gynecology

Background:

  • Circular RNAs (circRNAs) are stable, non-coding RNA molecules forming a closed loop, distinct from linear RNA.
  • They function as miRNA sponges, influence transcription/splicing, and bind proteins, with cytoplasmic localization.
  • Three main types exist: exonic circRNA (ecRNA), intronic circRNA (ciRNA), and exon-intronic circRNA.

Purpose of the Study:

  • To review the role of circRNAs in gynecological tumors.
  • To explore circRNAs as potential biomarkers and therapeutic targets in reproductive cancers.

Main Methods:

  • Literature search of PubMed database up to January 2019.
  • Keywords used: "circular RNA", "database", and "reproductive tumor".
  • Selection of original articles and reviews.

Main Results:

  • CircRNAs are implicated in the development of ovarian epithelial tumors, ovarian carcinoma, and cervical carcinoma.
  • Evidence suggests circRNAs play a role in the pathogenesis of these gynecological malignancies.
  • Potential utility of circRNAs as diagnostic biomarkers and therapeutic targets is indicated.

Conclusions:

  • Circular RNAs are significantly involved in gynecological tumor development.
  • This review provides a foundation for further research into circRNA's role in gynecological oncology.

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