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Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
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Resorbable Versus Nonresorbable Membranes: When and Why?
Noel Ye Naung1, Ehab Shehata2, Joseph E Van Sickels1
1Division of Oral and Maxillofacial Surgery, Chandler Medical Center, College of Dentistry, University of Kentucky, D508, 800 Rose Street, Lexington, KY 40536-0297, USA.
Dental Clinics of North America
|May 18, 2019
Summary
Guided bone regeneration uses resorbable or nonresorbable membranes. Clinical studies show no significant difference between membrane types for most applications, with choice depending on defect and graft material.
Area of Science:
- Biomaterials Science
- Periodontology
- Oral Surgery
Background:
- Guided bone regeneration (GBR) is a key technique in reconstructive dentistry.
- Membranes are crucial for GBR, preventing soft tissue ingrowth while allowing bone formation.
- Material properties like biocompatibility, space-making ability, and permeability influence GBR outcomes.
Purpose of the Study:
- To review the properties and clinical performance of resorbable and nonresorbable membranes used in guided bone regeneration.
- To compare the efficacy of different membrane types based on available clinical evidence.
Main Methods:
- Systematic review and meta-analysis of clinical trials comparing resorbable and nonresorbable membranes.
- Evaluation of membrane characteristics including biocompatibility, space maintenance, barrier function, and handling.
Main Results:
- Commercially available nonresorbable membranes include e-PTFE (e.g., Gore-Tex) and d-PTFE (e.g., Cytoplast), and titanium mesh.
- Resorbable membranes are derived from natural or synthetic sources.
- No statistically significant differences were found between resorbable and nonresorbable membranes in most clinical indications.
Conclusions:
- Both resorbable and nonresorbable membranes are effective in guided bone regeneration.
- The selection of membrane material should be tailored to the specific grafting materials and the nature of the bone defect.
- Further research may focus on optimizing membrane properties for specific clinical scenarios.
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