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Updated: Jan 24, 2026

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
Published on: June 14, 2024
[HIV Restriction Factors and Their Ambiguous Role during Infection]
A A Zotova1,2,3, A A Atemasova1, A V Filatov4
1Moscow State University, Faculty of Biology, Moscow, 119991 Russia.
Abstract:
Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.
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