Related Experiment Video
Updated: Jan 24, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Dually Cross-Linked Supramolecular Hydrogel as Surface Plasmon Resonance Sensor for Small Molecule Detection
Jie Li1, Chendong Ji2, Xiaoqian Yu1
1Department of Chemistry, Paderborn University, Warburgerstraße 100, D-33098, Paderborn, Germany.
Abstract:
Dually cross-linked supramolecular hydrogels (DCSH) are designed to show responsive properties while maintaining the gel structure by introducing two different kinds of cross-links. This is realized by utilizing a photo-cross-linker for permanent cross-linking and β-cyclodextrin (β-CD) and ferrocene (Fc) as host-guest recognition pair. The DCSH shows increased swelling in the presence of the small target molecule adamantane amine (Ada). Ada can break the non-covalent bonding between β-CD and Fc through competitive molecular guest interaction with β-CD. By using a combination of surface plasmon resonance and optical waveguide spectroscopy, it is possible to use this behavior to construct a reversible sensor for specific small molecule detection.
Related Concept Videos
Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
Crossing Over
Resonance
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Monohybrid Crosses
Cross-Sectional Research

