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Consensus Statement on Circulating Biomarkers for Advanced Prostate Cancer.

Semini Sumanasuriya1, Aurelius Omlin2, Andrew Armstrong3

  • 1Institute of Cancer Research, Sutton, UK; The Royal Marsden Hospital NHS Trust, London, UK.

European Urology Oncology
|May 18, 2019
PubMed
Summary

Consensus among experts on circulating biomarkers in advanced prostate cancer (PC) is needed. This report outlines key areas of controversy and expert opinions to guide future biomarker development for better PC patient care.

Keywords:
Advanced prostate cancerAndrogen receptor splice variantsCell-free DNACirculating biomarkersCirculating tumour cellsConsensus

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Prostate Cancer Research

Background:

  • Advanced prostate cancer (PC) management increasingly utilizes circulating biomarkers, including circulating tumor cells and cell-free nucleic acids, for monitoring and prediction.
  • A significant lack of consensus and standardization exists regarding the analysis, reporting, and clinical integration of these circulating biomarkers.
  • A consensus meeting was convened to address these critical issues in the field.

Purpose of the Study:

  • To present a consensus statement on the application of circulating biomarkers in advanced prostate cancer (PC).
  • To identify and address key areas of controversy in the field of circulating biomarkers for PC management.
  • To provide expert guidance for the development and implementation of circulating biomarker assays.

Main Methods:

  • A panel of 18 international experts in prostate cancer (PC) circulating biomarkers developed consensus questions.
  • A modified Delphi process was employed, involving anonymous voting by the expert panel on 50 predefined questions.
  • Voting was based on expert opinion, not a formal literature review or meta-analysis.

Main Results:

  • Four critical areas of controversy were identified: clinical utility, unmet needs, essential assays, and development steps for circulating biomarkers in PC.
  • Expert opinions on these topics varied, with outcomes detailed in the article and supplementary materials.
  • The consensus highlighted the need for reproducibility and variability studies in circulating biomarker development.

Conclusions:

  • The presented expert voting results offer guidance for the future development of circulating biomarkers in prostate cancer (PC) care.
  • Further research and specifically designed trials are crucial to address areas such as reproducibility and variability.
  • Standardization and consensus are vital for the effective clinical integration of circulating biomarkers in advanced PC.