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Related Experiment Video

Updated: Jan 24, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Septic myocardial calcification: A case report.

Aniello Maiese¹, Federico Manetti², Raffaele La Russa¹

¹Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Viale Regina Elena 336, 00161, Italy; IRCCS Neuromed, Via Atinense 18, Pozzilli, 86077, Italy.

Journal of Forensic and Legal Medicine

|May 18, 2019

Summary

This study reports a rare case of myocardial calcification in a patient with sepsis. Histological examination revealed extensive calcification in the right atrial wall, highlighting a potential complication of severe sepsis.

Keywords:

Myocardial calcification Postmortem diagnosis Sepsis Septic myocardial dysfunction

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Published on: November 15, 2024

Area of Science:

Pathology
Cardiology
Infectious Diseases

Background:

Sepsis can lead to various cardiac histological changes, including myocytolysis and fibrosis.
Septic myocardial calcification is an exceedingly rare condition with unclear pathogenesis.
Existing knowledge on myocardial calcification primarily recognizes metastatic or dystrophic mechanisms.

Observation:

A 72-year-old male with polytrauma developed sepsis on day 110.
Transesophageal echocardiogram identified right atrial wall calcification; no predisposing systemic factors were noted.
The patient died from septic shock and multi-organ failure on day 149.

Findings:

Autopsy confirmed a calcified, firm right atrial wall with a greenish-brown formation.
Histological examination revealed extensive subendocardial calcification with fibrin deposition and surrounding fibrosis.

Implications:

This case expands the understanding of rare cardiac manifestations of severe sepsis.
It underscores the importance of considering myocardial calcification in sepsis survivors with cardiac abnormalities.
Further research into the specific mechanisms of sepsis-induced myocardial calcification is warranted.