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Related Experiment Video

Updated: Jan 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Repurposing azithromycin for neonatal neuroprotection.

John D E Barks¹, Yiqing Liu², Lu Wang³

¹Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA. jbarks@med.umich.edu.

Pediatric Research

|May 18, 2019

Summary

Azithromycin demonstrated neuroprotective effects in a neonatal rodent model of hypoxic-ischemic brain injury. This antibiotic improved functional outcomes and reduced brain damage, suggesting potential for clinical trials.

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Last Updated: Jan 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

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Published on: January 27, 2023

Area of Science:

Neuroscience
Pharmacology
Neonatal Medicine

Background:

Inflammation plays a key role in neonatal hypoxic-ischemic brain injury.
Azithromycin, an antibiotic with anti-inflammatory properties, was investigated for neuroprotection.

Purpose of the Study:

To evaluate the neuroprotective efficacy of azithromycin in a neonatal rodent model of hypoxic-ischemic brain injury.

Main Methods:

Neonatal rats underwent carotid artery ligation and hypoxia.
Sensorimotor function and brain damage were assessed after azithromycin or saline treatment.
Various dosing regimens and treatment timings were explored.

Main Results:

Azithromycin administration improved functional outcomes and reduced brain damage in a dose-dependent manner.
Treatment efficacy decreased with delayed administration post-hypoxia.
Multiple azithromycin injections over 48 hours showed greater benefits than a single dose.

Conclusions:

Azithromycin exhibits neuroprotective effects in a neonatal rodent model of hypoxic-ischemic brain injury.
Further studies in complementary models are warranted to support clinical trial evaluation for neonatal neuroprotection.