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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Beyond the Clinical Trials: Off-Protocol Therapeutic Hypothermia

Naomi T Laventhal1, John D E Barks1

  • 1Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Michigan Medicine-University of Michigan Medical School, 8-621 C.S. Mott Children's Hospital, SPC 4254, 1540 East Hospital Drive, Ann Arbor, MI 48105-4254, USA.

Clinics in Perinatology
|February 25, 2022
PubMed
Summary

Mild therapeutic hypothermia effectively treats hypoxic encephalopathy in newborns. Further research is needed to optimize cooling protocols and consider treatment for infants outside initial study criteria.

Keywords:
Hypoxic ischemic encephalopathyNeuroprotectionResearch ethicsTargeted temperature managementTherapeutic hypothermia

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